Sodium Iodide → 3-Benzyl-6-[2-(3-chloro-4-methoxy-phenyl)ethyl]-6-cyclopentyl-tetrahydropyran-2,4-dione

HRID 858761

Reaktionsgleichung

Reaktionsgleichung von HRID 858761
C1CCN2C(=NCCC2)CC1.[Cl:12][C:13]1[CH:14]=[C:15]([CH2:21][CH2:22][C:23]2([CH:31]3[CH2:35][CH2:34][CH2:33][CH2:32]3)[O:28][C:27](=[O:29])[CH2:26][C:25](=[O:30])[CH2:24]2)[CH:16]=[CH:17][C:18]=1[O:19][CH3:20].[CH2:36](Br)[C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1.[I-].[Na+]>C1C=CC=CC=1>[CH2:36]([CH:26]1[C:25](=[O:30])[CH2:24][C:23]([CH2:22][CH2:21][C:15]2[CH:16]=[CH:17][C:18]([O:19][CH3:20])=[C:13]([Cl:12])[CH:14]=2)([CH:31]2[CH2:35][CH2:34][CH2:33][CH2:32]2)[O:28][C:27]1=[O:29])[C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1

Komponenten

6

Edukt 4

HCID 5238Sodium IodideHCID 7498Benzyl BromideHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 160761096-(3-chloro-4-methoxyphenethyl)-6-cyclopentyl-dihydro-3H-pyran-2,4-dione

Produkt 1

HCID 167288503-Benzyl-6-[2-(3-chloro-4-methoxy-phenyl)ethyl]-6-cyclopentyl-tetrahydropyran-2,4-dioneAusbeute 14,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

DBU (28.6 ul, 0.191 mmol) was added to a solution of 6-[2-(3-chloro-4-methoxyphenyl)ethyl]-6-cyclopentyldihydro-2H-pyran-2,4(3H)-dione (60.6 mg, 0.172 mmol) in benzene (2.0 ml), under an atmosphere of argon. Benzyl bromide (20.5 ul, 0.172 mmol) was then added. The reaction mixture was stirred at room temperature for 20 minutes, followed by the addition of 5 crystals of sodium iodide. The reaction mixture was stirred for a further 24 hrs, after which time the mixture was filtered through a plug of Celite. The filtrate was concentrated in vacuo and the residue purified by prep HPLC to afford the title compound as a white solid (11.1 mg).

Aufarbeitung

  1. stirringThe reaction mixture was stirred for a further 24 hrs
  2. filtrationafter which time the mixture was filtered through a plug of Celite
  3. concentrationThe filtrate was concentrated in vacuo
  4. customthe residue purified by prep HPLC

Quellen und Nachweise

ORD-Eintrag
ord-56c0f0ad29c24aa5998595fde2fa2480
Quelldatensatz
uspto-grants-2006_12
Patentnummer
US07148226B2

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