Acetic Acid → HCID 178522205, Verbindung

HRID 861746Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 861746
[OH:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[C:8](=[C:18]3[CH2:23][CH2:22][N:21]([C:24]([NH:26][C:27]4[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=4)=[O:25])[CH2:20][CH2:19]3)[C:9]3[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:10]=3[CH2:11][CH2:12][C:3]=12.C(O)(=O)C.[Br:37]Br.C(O)(=O)C>O>[Br:37][C:7]1[C:2]([OH:1])=[C:3]2[CH2:12][CH2:11][C:10]3[CH:13]=[C:14]([Cl:17])[CH:15]=[CH:16][C:9]=3[C:8](=[C:18]3[CH2:23][CH2:22][N:21]([C:24]([NH:26][C:27]4[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=4)=[O:25])[CH2:20][CH2:19]3)[C:4]2=[N:5][CH:6]=1

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 87433071bromine AcOHHCID 178522206HCID 178522206, Verbindung

Produkt 1

HCID 178522205HCID 178522205, VerbindungAusbeute 67 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of the title compound from Example 263 (0.34 grams) and glacial acetic acid (10 mL) was added a 0.7M bromine-acetic acid solution (4 mL) at 25° C. under N2. After 10 minutes, water was added and the resulting solid was filtered and washed with water several times and dried to give the title compound (Yield 0.31 grams, 67%, MH+ 527).

Aufarbeitung

  1. filtrationthe resulting solid was filtered
  2. washwashed with water several times
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-517f6d674c804bfa818bda770297fb1b
Quelldatensatz
uspto-grants-1998_02
Patentnummer
US05714609

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