1-Methyl-1,2,3,6-tetrahydropyridin-1-ium-5-carboxylic acid;chloride → 1-methylpiperidine-3-carboxylic Acid

HRID 862453Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 862453
[CH3:1][NH+:2]1[CH2:7][C:6]([C:8]([OH:10])=[O:9])=[CH:5][CH2:4][CH2:3]1.[Cl-]>O.[Pd]>[CH3:1][N:2]1[CH2:3][CH2:4][CH2:5][CH:6]([C:8]([OH:10])=[O:9])[CH2:7]1

Komponenten

4

Edukt 1

HCID 223681-Methyl-1,2,3,6-tetrahydropyridin-1-ium-5-carboxylic acid;chloride

Produkt 1

HCID 27369371-methylpiperidine-3-carboxylic AcidAusbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 962WaterLösungsmittel

Versuchsvorschrift

Arecaidine hydrochloride (4 grams) (22.6 mmoles) was hydrogenated in water (100 ml) using 10% Pd-C at 40 psi at 25° C. for 24 hours. The catalyst was filtered off and washed with water. The aqueous solution was shaken with BioRad AG1X8 resin (OH- form) (23 ml bed) and after 5 minutes the resin was filtered off and washed with water. The aqueous solution was evaporated to give the title compound (Yield: 2.95 grams, 92%).

Aufarbeitung

  1. customat 25° C.
  2. customfor 24 hours
  3. filtrationThe catalyst was filtered off
  4. washwashed with water
  5. filtrationwas filtered off
  6. washwashed with water
  7. customThe aqueous solution was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-9d856d4f9762485e9223b5add7007a94
Quelldatensatz
uspto-grants-1998_02
Patentnummer
US05719148

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