Water → Trichlorothiophene-3-sulfonyl chloride

Temperatur

60 °C

A mixture of 2,5-dichlorothiophene-3-sulfonyl chloride (1.2 g, 5 mmol) and sulfur monochloride (10 mg) in sulfuryl chloride (500 mg) was heated at 60° C. for 30 min, at which time was added dropwise a mixture of aluminum trichloride (10 mg) in sulfuryl chloride (500 mg). The reaction was heated at 60° C. for an additional 3 hours, at which time it was allowed to cool to ambient temperature. Cold water (20 mL) was added and the reaction extracted with dichloromethane (2×20 mL). The combined organic layers were washed with saturated sodium bicarbonate solution, dried (Mg2SO4) and concentrated to furnish a tan solid (420 mg, 33%).

1. additionwas added dropwise
2. temperatureThe reaction was heated at 60° C. for an additional 3 hours, at which time it
3. temperatureto cool to ambient temperature
4. extractionthe reaction extracted with dichloromethane (2×20 mL)
5. washThe combined organic layers were washed with saturated sodium bicarbonate solution
6. dry with materialdried (Mg2SO4)
7. concentrationconcentrated

ORD-Eintrag

ord-2f30ba84e4194cd6b9cb4784c4f11ab7

Quelldatensatz

uspto-grants-2006_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07091204B2