Isopropanol → Tert-butyl 2-bromo-2-(diethoxyphosphoryl)acetate

HRID 864525Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 864525
[CH2:1]([O:3][P:4]([C:9](Br)([Br:17])[C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])([O:6][CH2:7][CH3:8])=[O:5])[CH3:2].C(O)(C)C.[Sn](Cl)Cl>O>[CH2:1]([O:3][P:4]([CH:9]([Br:17])[C:10]([O:12][C:13]([CH3:14])([CH3:16])[CH3:15])=[O:11])([O:6][CH2:7][CH3:8])=[O:5])[CH3:2]

Komponenten

5

Edukt 3

HCID 3776IsopropanolHCID 24479Stannous ChlorideHCID 21263367HCID 21263367, Verbindung

Produkt 1

HCID 21263365Tert-butyl 2-bromo-2-(diethoxyphosphoryl)acetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

Combine t-butyl diethylphosphonodibromoacetate (75.6 g, 184 mmol) and isopropanol (190 mL). Cool to 0° C. Add a solution of tin (II) chloride (33.2 g, 175 mmol) in water (190 mL). After the addition is complete, warm to ambient temperature. After 1 hour, extract the reaction mixture three times with chloroform. Combine the organic layers and extract with water, dry over MgSO4, filter, and evaporate in vacuo to give the title compound.

Aufarbeitung

  1. additionAfter the addition
  2. temperaturewarm to ambient temperature
  3. extractionextract the reaction mixture three times with chloroform
  4. extractionextract with water
  5. dry with materialdry over MgSO4
  6. filtrationfilter
  7. customevaporate in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-6567ebc10bb04297a2fee93a840de8d8
Quelldatensatz
uspto-grants-1996_10
Patentnummer
US05563157

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