Tobramycin Sulphate Salt → Tobramycin trans-traumatate

HRID 865826

Reaktionsgleichung

Reaktionsgleichung von HRID 865826
[C:1]([OH:16])(=[O:15])/[CH:2]=[CH:3]/[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13].[CH2:17]1[C@@H:22]([NH2:23])[C@H:21]([O:24][C@H:25]2[O:30][C@H:29]([CH2:31][OH:32])[C@@H:28]([OH:33])[C@H:27]([NH2:34])[C@H:26]2[OH:35])[C@@H:20]([OH:36])[C@H:19]([O:37][C@H:38]2[O:43][C@H:42]([CH2:44][NH2:45])[C@@H:41]([OH:46])[CH2:40][C@H:39]2[NH2:47])[C@H:18]1[NH2:48].OS(O)(=O)=O>O>[CH2:17]1[C@@H:22]([NH2:23])[C@H:21]([O:24][C@H:25]2[O:30][C@H:29]([CH2:31][OH:32])[C@@H:28]([OH:33])[C@H:27]([NH2:34])[C@H:26]2[OH:35])[C@@H:20]([OH:36])[C@H:19]([O:37][C@H:38]2[O:43][C@H:42]([CH2:44][NH2:45])[C@@H:41]([OH:46])[CH2:40][C@H:39]2[NH2:47])[C@H:18]1[NH2:48].[C:1]([O-:16])(=[O:15])/[CH:2]=[CH:3]/[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]([O-:14])=[O:13]

Komponenten

4

Edukt 2

HCID 62005Tobramycin Sulphate SaltHCID 5283028Traumatic Acid

Produkt 1

HCID 131719627Tobramycin trans-traumatate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Reaktionsbedingungen

Temperatur
4 °C

Versuchsvorschrift

11.4 g of trans-traumatic traumatic acid (50 mmol) are suspended in 200 ml of cool water at 4° C., A solution of 14.3 g of tobramycin sulfate (20mmol) in 200 ml of water is eluted through a column cooled to 4° C. containing 150 ml of [OH--] Dowex 1×8 resin. The eluate free from sulfate is collected into the suspension of traumatic acid kept under continuous stirring at 4° C. The resulting solution is frozen and lyophilized.

Aufarbeitung

  1. additioncontaining 150 ml of [OH--] Dowex 1×8 resin
  2. customThe eluate free from sulfate is collected into the suspension of traumatic acid
  3. temperatureThe resulting solution is frozen

Quellen und Nachweise

ORD-Eintrag
ord-0a400e07c9f64a6c93bccec9c523a1ca
Quelldatensatz
uspto-grants-1996_10
Patentnummer
US05567716

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