Tobramycinsulfat

Tobramycin Sulphate Salt

HCID 62005CAS 49842-07-1

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Grundinformationen

Standard-SMILES: NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](N)C[C@@H]1O.O=S(=O)(O)O
InChIKey: ZEUUPKVZFKBXPW-TWDWGCDDSA-N
Summenformel: C18H39N5O13S
Durchschnittliche Molmasse: 565,6 g/mol

Überblick

Tobramycin Sulfate can cause developmental toxicity according to state or federal government labeling requirements.

Namen und Bezeichner

Bevorzugter Name: Tobramycin Sulphate Salt
IUPAC: (2S,3R,4S,5S,6R)-4-amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol;sulfuric acid
Lokaler Name: Tobramycinsulfat
Englischer Name: Tobramycin sulphate
Summenformel: C18H39N5O13S
Molmasse: 565.59

Namen und Synonyme

Tobramycin Sulphate SaltMLS000069826MFCD00133864SMR000058891Tobramycin (sulfate)C18H39N5O13S(2S,3R,4S,5S,6R)-4-amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol;sulfuric acidTobramycin Sulfate Salt; O-3-amino-3-deoxy-a-D-glucopyranosyl-(1?6)-O-[2,6-diamino-2,3,6-trideoxy-a-D-ribo-hexopyranosyl-(1?4)]-2-deoxy-D-streptamine Sulfate (5:2)Tobramycin Impurity 4Opera_ID_1050SCHEMBL2837Nebramycin Factor 6 (sulfate);Deoxykanamycin B (sulfate)

Weitere Namen anzeigen

Tobramycin sulfateTOBRAMYCIN SULPHATEobracinetenemicinTOBRAMYCIN SLIPHATETOBRAMYCIN SULPHATETobraMycin Sulfate API1-epitobramycinsulfateTOBRAMYCIN SULFATE SALTTobramycin Monosulphate Salt

126777-32-0CHEMBL1200780HMS2230J04EBC-98152AKOS025310614(2S,3R,4S,5S,6R)-4-Amino-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-6-(hydroxymethyl)oxane-3,5-diol SulfateNS00089156Tobramycin sulfate salt, aminoglycoside antibiotic

Datenbank-Bezeichner

CAS: 49842-07-1
PubChem CID: 62005
ChEMBL: CHEMBL1200780

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA): 351 Å²
H-Brücken-Donoren: 12
H-Brücken-Akzeptoren: 18
Frei drehbare Bindungen: 6
Schwere Atome: 37
Formalladung: 0
Komplexität: 690

Physikochemische Eigenschaften

storage temp.: 2 · 2-8°C
Löslichkeit: Methanol (Slightly), Water (Sparingly)
Aggregatzustand: Powder
Farbe: White to off-white
Wasserlöslichkeit: Soluble in water (50 mg/ml).
Stabilität: Hygroscopic
InChIKey: ZEUUPKVZFKBXPW-SYOBZNKXNA-N
SMILES: OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O
CAS Datenbank: 49842 · 49842-07-1
EPA chemische Informationen: Tobramycin sulfate (49842-07-1)

Sicherheit und Regulatorisches

Sicherheitsdaten

wgk: 3
hs_code: 2941900000
risk_code: 61-20/21/22
hazard_code: T
safety_code: 53-22-36/37/39-45
Speicherklasse: 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
Hazard Classifications: Acute Tox. 4 DermalAcute Tox. 4 InhalationRepr. 1B

Chemie und Industrie

Anwendungen · 1 Eintrag

VerwendenTobramycin sulfate is used as an antibiotic which is used to treat various types of bacterial infections, particularly Gram-negative infections. It is especially effective against species of Pseudomonas. It is used to inhibit bacterial protein synthesis at the level of 30S (16S rRNA) and 70S ribosomal complex assembly. It is used to treat pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis and other soft-tissue infections. It is a potential therapy for sinus infections1. Product T1783 has been used to study antibiotic resistance2.