Water → N-ethyl-4-fluoroaniline

HRID 865928Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 865928
I[CH2:2][CH3:3].[F:4][C:5]1[CH:11]=[CH:10][C:8]([NH2:9])=[CH:7][CH:6]=1.C(=O)([O-])[O-].[K+].[K+].O>CN(C=O)C>[CH2:2]([NH:9][C:8]1[CH:10]=[CH:11][C:5]([F:4])=[CH:6][CH:7]=1)[CH3:3]

Komponenten

6

Edukt 4

HCID 962WaterHCID 6340IodoethaneHCID 97314-FluoroanilineHCID 11430Potassium Carbonate

Produkt 1

HCID 4962184N-ethyl-4-fluoroaniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

Iodoethane (3.6 ml) was added to a mixture of 4-fluoroaniline (4.26 ml) and potassium carbonate (6.9 g) in dry DMF (100 ml). After 18.5 h at 23°, the resulting suspension was poured into water (400 ml) and extracted with EA (400 ml). The organic extract was washed with water (200 ml) then saturated brine (200 ml), dried and evaporated. The residual oil was chromatographed with 2 to 3 to 4% EA in hexane as eluent to give the title compound (3.667 g) as a yellow oil.

Aufarbeitung

  1. extractionextracted with EA (400 ml)
  2. extractionThe organic extract
  3. washwas washed with water (200 ml)
  4. dry with materialsaturated brine (200 ml), dried
  5. customevaporated
  6. customThe residual oil was chromatographed with 2 to 3 to 4% EA in hexane as eluent

Quellen und Nachweise

ORD-Eintrag
ord-f3ee23012faf4bc980a61779569cdba7
Quelldatensatz
uspto-grants-1996_10
Patentnummer
US05569654

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