Formic Acid → 6-amino-5-formamido-1-propyl-2,4-(1H,3H)-pyrimidinedione

HRID 867945

Reaktionsgleichung

Reaktionsgleichung von HRID 867945
[N:1]([O-])=O.[Na+].[NH2:5][C:6]1[N:11]([CH2:12][CH2:13][CH3:14])[C:10](=[O:15])[NH:9][C:8](=[O:16])[CH:7]=1.[CH:17]([OH:19])=O>O.[Pt]>[NH2:5][C:6]1[N:11]([CH2:12][CH2:13][CH3:14])[C:10](=[O:15])[NH:9][C:8](=[O:16])[C:7]=1[NH:1][CH:17]=[O:19]

Komponenten

6

Edukt 3

HCID 284Formic AcidHCID 1045626-Amino-1-propyluracilHCID 23668193Sodium Nitrite

Produkt 1

HCID 159313106-amino-5-formamido-1-propyl-2,4-(1H,3H)-pyrimidinedione

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23939PlatinumKatalysatorHCID 962WaterLösungsmittel

Versuchsvorschrift

Sodium nitrite (127 kg) was dissolved in water and added to suspension of 6-amino-1-propyl-2,4-(1H,3H)-pyrimidinedione (300 kg) in formic acid (1 400 kg). Pt/C 5 % was added and the reaction mixture was heated to 40°-80° C. The catalyst was filtered off, formic acid was distilled off and ethanol (870 kg) was added. The product was precipitated by cooling and isolated by centrifugation, washed with ethanol/water and used directly in Example 2.

Aufarbeitung

  1. temperaturethe reaction mixture was heated to 40°-80° C
  2. filtrationThe catalyst was filtered off
  3. distillationformic acid was distilled off
  4. additionethanol (870 kg) was added
  5. customThe product was precipitated
  6. temperatureby cooling
  7. customisolated by centrifugation
  8. washwashed with ethanol/water

Quellen und Nachweise

ORD-Eintrag
ord-c989df1d00ac4daeaf6f9d8b1d9d8be3
Quelldatensatz
uspto-grants-1988_10
Patentnummer
US04777255

Verknüpfte Notizen

Wird geladen…