Water → HCID 86722240, Verbindung

HRID 869391Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 869391
[NH2:1][C:2]1[C:6]2[C:7]([Cl:13])=[C:8]([O:11][CH3:12])[CH:9]=[CH:10][C:5]=2[O:4][C:3]=1[C:14](=[O:25])[CH:15]=[CH:16][C:17]1[N:18]=[C:19]([CH:22]([CH3:24])[CH3:23])[S:20][CH:21]=1.O>CC(O)=O.OP(O)(O)=O>[Cl:13][C:7]1[C:6]2[C:2]3[NH:1][CH:16]([C:17]4[N:18]=[C:19]([CH:22]([CH3:23])[CH3:24])[S:20][CH:21]=4)[CH2:15][C:14](=[O:25])[C:3]=3[O:4][C:5]=2[CH:10]=[CH:9][C:8]=1[O:11][CH3:12]

Komponenten

5

Edukt 2

HCID 962WaterHCID 86722239HCID 86722239, Verbindung

Produkt 1

HCID 86722240HCID 86722240, VerbindungAusbeute 108,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 1004Phosphoric AcidLösungsmittel

Versuchsvorschrift

10A (9.96 g, 26.43 mmol) was dissolved in AcOH (50 mL) and H3PO4 (50 mL). The solution was refluxed for 2 hours. TLC monitored the reaction. After the reaction completed, the reaction mixture was cooled to room temperature and poured into water (200 mL) The brown precipitates were collected by filtration and dried to give product 10B (10.8 g), which was used for the next step directly.

Aufarbeitung

  1. temperatureThe solution was refluxed for 2 hours
  2. customthe reaction
  3. custombrown precipitates
  4. filtrationwere collected by filtration
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-be5b8a68658446a68a3c0d5d799e4af6
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08969373B2

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