Bromine → (S)-tert-Butyl(1-(4-(3-bromoimidazo[1,2-b]pyridazin-6-yl)piperazin-1-yl)-4-methyl-1-oxopentan-2yl)carbamate

HRID 870783Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 870783
[C:1]([O:5][C:6](=[O:30])[NH:7][C@@H:8]([CH2:26][CH:27]([CH3:29])[CH3:28])[C:9]([N:11]1[CH2:16][CH2:15][N:14]([C:17]2[CH:18]=[CH:19][C:20]3[N:21]([CH:23]=[CH:24][N:25]=3)[N:22]=2)[CH2:13][CH2:12]1)=[O:10])([CH3:4])([CH3:3])[CH3:2].[Br:31]Br>CC(O)=O>[C:1]([O:5][C:6](=[O:30])[NH:7][C@@H:8]([CH2:26][CH:27]([CH3:28])[CH3:29])[C:9]([N:11]1[CH2:12][CH2:13][N:14]([C:17]2[CH:18]=[CH:19][C:20]3[N:21]([C:23]([Br:31])=[CH:24][N:25]=3)[N:22]=2)[CH2:15][CH2:16]1)=[O:10])([CH3:4])([CH3:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 86696490(S)-tert-Butyl (1-(4-(imidazo[1,2-b]pyridazin-6-yl)piperazin-1-yl)-4-methyl-1-oxopentan-2-yl)carbamate

Produkt 1

HCID 89805288(S)-tert-Butyl(1-(4-(3-bromoimidazo[1,2-b]pyridazin-6-yl)piperazin-1-yl)-4-methyl-1-oxopentan-2yl)carbamate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

To 104 mg (0.25 mmol) of (S)-tert-butyl(1-(4-(imidazo[1,2-b]pyridazin-6-yl)piperazin-1-yl)-4-methyl-1-oxopentan-2-yl)carbamate dissolved in 5 mL of AcOH was added bromine (48 mg, 0.3 mmol) and the resulting mixture was stirred at room temperature. After 0.25 hr, the reaction was done, and concentrated by rotavap and then by high vacuum pump to obtain 139 mg (100% yield) of mono-acetic acid salt of the desired product.

Aufarbeitung

  1. concentrationconcentrated by rotavap

Quellen und Nachweise

ORD-Eintrag
ord-7191e60995214bea91a280d61be7c6ea
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08969565B2

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