Hydrochloric Acid → Octanoate

HRID 871800

Reaktionsgleichung

Reaktionsgleichung von HRID 871800
[C:1]([O-:10])(=[O:9])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[Na+].[CH3:12][C@@H:13]1[N:34]2[C:17]3[C:18]([C:30]([C:32]([C:35]([OH:37])=[O:36])=[CH:33]2)=[O:31])=[CH:19][C:20]([F:29])=[C:21]([N:22]2[CH2:27][CH2:26][N:25]([CH3:28])[CH2:24][CH2:23]2)[C:16]=3[O:15][CH2:14]1.Cl>O>[CH3:12][C@@H:13]1[N:34]2[C:17]3[C:18]([C:30]([C:32]([C:35]([OH:37])=[O:36])=[CH:33]2)=[O:31])=[CH:19][C:20]([F:29])=[C:21]([N:22]2[CH2:23][CH2:24][N:25]([CH3:28])[CH2:26][CH2:27]2)[C:16]=3[O:15][CH2:14]1.[C:1]([O-:10])(=[O:9])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 149096LevofloxacinHCID 23664772Sodium octanoate

Produkt 2

HCID 119389OctanoateHCID 149096Levofloxacin

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

One gram of sodium octanoate and one gram of levofloxacin were dissolved in 100 ml water. The pH was slowly adjusted to 6.0 by the addition of 1 M HCl. As the pH decreased, levofloxacin became protonated formed an insoluble HIP with the negatively charged octanoate. The precipitate was gathered by filtration to remove excess levofloxacin, dissolved sodium octanoate/octanoic acid, and salt. The sample was lyophilized overnight.

Quellen und Nachweise

ORD-Eintrag
ord-3c6fcf879372438aa17574c118390070
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08974814B2

Verknüpfte Notizen

Wird geladen…