Hydrazine hydrate (1:1) → 5-Bromo-2-hydrazinyl-3-methylpyridine

HRID 873992Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 873992
O.[NH2:2][NH2:3].[Br:4][C:5]1[CH:6]=[C:7]([CH3:12])[C:8](Cl)=[N:9][CH:10]=1>COCCO>[Br:4][C:5]1[CH:6]=[C:7]([CH3:12])[C:8]([NH:2][NH2:3])=[N:9][CH:10]=1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 2854345-Bromo-2-chloro-3-methylpyridine

Produkt 1

HCID 534029825-Bromo-2-hydrazinyl-3-methylpyridineAusbeute 49,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 80192-MethoxyethanolLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

Hydrazine hydrate (119 mL, 2422 mmol) was added to a suspension of 5-bromo-2-chloro-3-methylpyridine (50 g, 242 mmol) in 2-methoxyethanol (250 mL). The resulting solution was stirred 30 h at 120° C. and concentrated. The yellow residue was purified by trituration with H2O to provide the title compound (24 g) as a colorless solid. tR: 0.39 min (LC-MS 2); ESI-MS: 201.9 [M+H]+ (LC-MS 2)

Aufarbeitung

  1. concentrationconcentrated
  2. customThe yellow residue was purified by trituration with H2O

Quellen und Nachweise

ORD-Eintrag
ord-fda35ec996e743919d41ab1c27490192
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08975417B2

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