2-(Benzylthio)-8-ethoxy-5,6-dihydroquinazoline → 2-(benzylthio)-6,7-dihydroquinazolin-8(5H)-one

HRID 875122

Reaktionsgleichung

Reaktionsgleichung von HRID 875122
[CH2:1]([S:8][C:9]1[N:18]=[CH:17][C:16]2[CH2:15][CH2:14][CH:13]=[C:12]([O:19]CC)[C:11]=2[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)(=O)C.O>[CH2:1]([S:8][C:9]1[N:18]=[CH:17][C:16]2[CH2:15][CH2:14][CH2:13][C:12](=[O:19])[C:11]=2[N:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 1

HCID 574441122-(Benzylthio)-8-ethoxy-5,6-dihydroquinazoline

Produkt 1

HCID 574441132-(benzylthio)-6,7-dihydroquinazolin-8(5H)-oneAusbeute 74 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

1.5 g (5 mmol) of 2-(benzylthio)-8-ethoxy-5,6-dihydroquinazoline were dissolved in 50 mL of acetic acid and 3 mL of water. The solution was stirred at refluxing temperature for 4 hours. The solvent was then removed under vacuum, the residue partitioned between dichloromethane and a NaHCO3 saturated solution. The organic layer was dried over anhydrous Na2SO4 and concentrated, giving 1.0 g (74% yield) of the title compound.

Aufarbeitung

  1. temperatureat refluxing temperature for 4 hours
  2. customThe solvent was then removed under vacuum
  3. customthe residue partitioned between dichloromethane
  4. dry with materialThe organic layer was dried over anhydrous Na2SO4
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-1719f120f0114d8ea6700fbf508e3516
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08981089B2

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