Hydrochloric Acid → Thieno[3,2-c]pyridine-2-carboxylic acid

HRID 876769Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 876769
[S:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[C:2]1[C:10]([O:12]C)=[O:11].O[Li].O.Cl>CO.O>[S:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[C:2]1[C:10]([OH:12])=[O:11]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 22047666Methyl thieno[3,2-c]pyridine-2-carboxylate

Produkt 1

HCID 13580293Thieno[3,2-c]pyridine-2-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of methyl thieno[3,2-c]pyridine-2-carboxylate (D-2) (12 g, 62.1 mmol) in MeOH (150 mL) and H2O (15 mL) was added LiOH.H2O (5.2 g, 124.2 mmol). The solution was stirred at room temperature overnight, and then acidified with 1N aqueous HCl. The resulting white precipitate was collected by filtration and air-dried to afford the title compound. MS (m/z): 179 (M)+.

Aufarbeitung

  1. filtrationThe resulting white precipitate was collected by filtration
  2. customair-dried

Quellen und Nachweise

ORD-Eintrag
ord-90be16a73ab14217a01601673cc6a8d7
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08987269B2

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