Formic Acid → HCID 86601051, Verbindung

HRID 883545

Reaktionsgleichung

Reaktionsgleichung von HRID 883545
[NH2:1][C:2]1[C:3](=[O:14])[NH:4][C:5](=[S:13])[N:6]([CH2:9][CH:10]([CH3:12])[CH3:11])[C:7]=1[NH2:8].O.[CH:16](O)=[O:17]>>[NH2:8][C:7]1[N:6]([CH2:9][CH:10]([CH3:11])[CH3:12])[C:5](=[S:13])[NH:4][C:3](=[O:14])[C:2]=1[NH:1][CH:16]=[O:17]

Komponenten

4

Edukt 3

HCID 284Formic AcidHCID 962WaterHCID 866010505,6-Diamino-1-isobutyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

Produkt 1

HCID 86601051HCID 86601051, VerbindungAusbeute 86 %

Versuchsvorschrift

5,6-Diamino-1-isobutyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one (Example 6 (c), 0.25 g, 1.2 mmol) was dissolved in formic acid (1.5 mL) and stirred at ambient temperature for 0.5 h. A pink precipitate started to form after a few minutes. Water was added and the resulting mixture stirred for 10 minutes. The pink solid was collected by filtration, washed with water and dried to yield the title compound (0.25 g, 86%). This material was used without further purification. NMR showed that the product was obtained as a mixture of two tautomers: formamide (major) and imino (minor).

Aufarbeitung

  1. customto form after a few minutes
  2. stirringthe resulting mixture stirred for 10 minutes
  3. filtrationThe pink solid was collected by filtration
  4. washwashed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-76865c3601e54770a4c6e970617cd5d6
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08236951B2

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