Dichloromethane → 6-Ethylpyridin-2-amine

HRID 883846

Reaktionsgleichung

Reaktionsgleichung von HRID 883846
CC1[N:3]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([CH2:14][CH3:15])[N:9]=2)C(C)=CC=1.Cl.NO.[OH-].[Na+].C(Cl)Cl>CCO.O>[CH2:14]([C:10]1[N:9]=[C:8]([NH2:3])[CH:13]=[CH:12][CH:11]=1)[CH3:15]

Komponenten

7

Edukt 4

HCID 6344DichloromethaneHCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 133983042-(2,5-Dimethyl-1H-pyrrol-1-yl)-6-ethylpyridine

Produkt 1

HCID 890216-Ethylpyridin-2-amine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

The product from Example 8a (4.93 g, 0.025 mol) was dissolved in a mixture of EtOH (80 mL) and water (30 mL). To this was added hydroxylamine hydrochloride (8.6 g, 0.123 mol) and the resulting mixture heated to 100° C. for 8 h. The reaction mixture was poured into dilute sodium hydroxide solution and the crude product isolated by extraction with CH2Cl2 and dried over MgSO4 filtered and concentrated under vacuum giving the title compound. The material was used as isolated.

Aufarbeitung

  1. dry with materialdried over MgSO4
  2. filtrationfiltered
  3. concentrationconcentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-a50a5ac9b3a8470bab5d13c658678c33
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08236950B2

Verknüpfte Notizen

Wird geladen…