Water → 2-hydroxy-4-morpholin-4-yl-benzoic Acid

To a stirred solution of 2-hydroxy-4-morpholin-4-yl-benzoic acid methyl ester (4.6 g; 19.4 mmol) in MeOH (120 mL) was added water (60 mL) and lithium hydroxide hydrate (4.08 g; 97 mmol). The resulting mixture was heated to 80° C. for 15 hours. The resulting mixture then was washed with EtOAc (3×60 mL), and cooled to 0° C. and acidified with 2 N aqueous hydrochloric acid to pH 4. The resulting precipitate was collected on a Buchner funnel with suction, washed with water, and air dried to provide the acid (4.16 g; 96%).

1. washThe resulting mixture then was washed with EtOAc (3×60 mL)
2. temperaturecooled to 0° C.
3. customThe resulting precipitate was collected on a Buchner funnel with suction
4. washwashed with water, and air
5. customdried
6. customto provide the acid (4.16 g; 96%)

ORD-Eintrag

ord-c96ded1140654f498d3436fed75aed8e

Quelldatensatz

uspto-grants-2012_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08242115B2