HCID 178418361, Verbindung → 3-Amino-5-(trifluoromethyl)-1,2-dihydropyridin-2-one

HRID 884984

Reaktionsgleichung

Reaktionsgleichung von HRID 884984
[OH:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][C:5]([C:11]([F:14])([F:13])[F:12])=[CH:4][N:3]=1.[H][H]>[Pd].CO>[NH2:8][C:7]1[C:2]([OH:1])=[N:3][CH:4]=[C:5]([C:11]([F:14])([F:12])[F:13])[CH:6]=1

Komponenten

5

Edukt 2

HCID 178418361HCID 178418361, VerbindungHCID 178526653HCID 178526653, Verbindung

Produkt 1

HCID 23157873-Amino-5-(trifluoromethyl)-1,2-dihydropyridin-2-oneAusbeute 99,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 3.13 g of 2-hydroxy-3-nitro-5-trifluoromethylpyridine, 40 ml of methanol and 0.85 g of 5% palladium on carbon was stirred under about one atmosphere of hydrogen at room temperature for two hours. The reaction mixture was filtered through Celite™. The filtrate was concentrated under reduced pressure to give 2.66 g of 3-amino-2-hydroxy-5-trifluoromethylpyridine.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through Celite™
  2. concentrationThe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-c5aa95dbbd68471cb46461c65ab3c1d7
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08242133B2

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