Acetic Acid → 2-oxo-1H,2H,3H-pyrrolo[2,3-b]pyridine-4-carbonitrile

HRID 888125Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 888125
Br[C:2]1(Br)[C:10]2[C:9]([C:11]#[N:12])=[CH:8][CH:7]=[N:6][C:5]=2[NH:4][C:3]1=[O:13].CC(O)=O>CC#N.[Zn]>[O:13]=[C:3]1[NH:4][C:5]2[N:6]=[CH:7][CH:8]=[C:9]([C:11]#[N:12])[C:10]=2[CH2:2]1

Komponenten

5

Edukt 2

HCID 176Acetic AcidHCID 69264126HCID 69264126, Verbindung

Produkt 1

HCID 692637962-oxo-1H,2H,3H-pyrrolo[2,3-b]pyridine-4-carbonitrile

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23994ZincKatalysatorHCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

To a stirred solution of 3,3-dibromo-2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile (4 g) in CH3CN (75 mL) was added AcOH (2 mL) followed by Zinc dust (4, 63 mmol). Mixture was stirred for 2 h at RT and was filtered. Solvent was evaporated and MeOH was added. A solid precipitated, which was filtered and dried.

Aufarbeitung

  1. filtrationwas filtered
  2. customSolvent was evaporated
  3. additionMeOH was added
  4. customA solid precipitated
  5. filtrationwhich was filtered
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-827029395fb14d1cb8aec7a5b996de41
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08247556B2

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