Diisopropylethylamine → HCID 58941998, Verbindung

HRID 888161Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 888161
[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([CH2:10][NH:11][C:12]2[N:20]=[CH:19][CH:18]=[CH:17][C:13]=2[C:14]([OH:16])=O)=[CH:2]1.[NH2:21][C:22]1[CH:31]=[C:30]2[C:25]([C:26]([CH3:34])([CH3:33])[CH2:27][C:28](=[O:32])[NH:29]2)=[CH:24][CH:23]=1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.CCN(C(C)C)C(C)C>O.CN(C=O)C>[CH3:33][C:26]1([CH3:34])[C:25]2[C:30](=[CH:31][C:22]([NH:21][C:14]([C:13]3[C:12]([NH:11][CH2:10][C:3]4[C:4]5[C:5](=[N:6][CH:7]=[CH:8][CH:9]=5)[NH:1][CH:2]=4)=[N:20][CH:19]=[CH:18][CH:17]=3)=[O:16])=[CH:23][CH:24]=2)[NH:29][C:28](=[O:32])[CH2:27]1

Komponenten

7

Edukt 4

HCID 81531DiisopropylethylamineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 144764787-Amino-4,4-dimethyl-3,4-dihydroquinolin-2(1H)-oneHCID 692655932-((1H-pyrrolo[2,3-b]pyridin-3-yl)methylamino)nicotinic acid

Produkt 1

HCID 58941998HCID 58941998, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

2-((1H-Pyrrolo[2,3-b]pyridin-3-yl)methylamino)nicotinic acid (100 mg, 0.37 mmol), 7-amino-4,4-dimethyl-3,4-dihydroquinolin-2(1H)-one (65 mg, 0.37 mmol), TBTU (133 mg, 0.41 mmol) and DIEA (0.07 mL, 0.41 mmol) was added to DMF (1 mL). The reaction was run at RT for 24 h. The reaction was then diluted with water and the resultant precipitate was filtered and purified using flash column to afford product. MS (ES+): 441.5 (M+H). Calc'd. for C25H24N6O2—440.20.

Aufarbeitung

  1. filtrationthe resultant precipitate was filtered
  2. custompurified
  3. customto afford product

Quellen und Nachweise

ORD-Eintrag
ord-3cd1cb525e31407dbf28509ee92f3a0a
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08247556B2

Notizen zur Reaktion

Wird geladen…