Diethyl Ether → HCID 135537121, Verbindung

HRID 892435Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 892435
Cl[C:2]1[CH:7]=[C:6]([OH:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][CH2:17][CH3:18])[N:3]=1.[CH2:19]([NH2:21])[CH3:20].C(OCC)C>C(O)C>[CH2:19]([NH:21][C:2]1[N:3]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][CH2:17][CH3:18])[NH:5][C:6](=[O:8])[CH:7]=1)[CH3:20]

Komponenten

5

Edukt 3

HCID 3283Diethyl EtherHCID 6341EthylamineHCID 178458304HCID 178458304, Verbindung

Produkt 1

HCID 135537121HCID 135537121, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

4-Chloro-6-hydroxy-2-(2-propoxyphenyl)pyrimidine (0.66 g) and ethylamine in ethanol (33%, 20 ml) was heated at 90° C. in a pressure vessel for 16 hours. The cooled reaction mixture was evaporated under reduced pressure to yield an oil which solidified on trituration with diethyl ether. The residue was recrystallised from isopropanol: diethyl ether, washed with water and recrystallised from isopropanol:water to yield the title compound, 0.47 g, m.p. 187°-8° C.

Aufarbeitung

  1. customThe cooled reaction mixture
  2. customwas evaporated under reduced pressure
  3. customto yield an oil which
  4. customThe residue was recrystallised from isopropanol
  5. washdiethyl ether, washed with water
  6. customrecrystallised from isopropanol

Quellen und Nachweise

ORD-Eintrag
ord-f17bc6c8a5b247e5bbd9ece180c9a8b2
Quelldatensatz
uspto-grants-1992_06
Patentnummer
US05118686

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