Ethyl formate → 2-Formylheptanonitrile

A solution of potassium tert-butoxide (18.9 g) in a mixed solvent system of tetrahydrofuran (150 ml) and toluene (100 ml) was heated to 75° . A solution of heptanonitrile (11.2 g) and ethyl formate (24 ml) in toluene (50 ml) was then added dropwise to the warm tert-butoxide solution. The reaction was stirred for 5 hours at 75° then cooled with an ice bath. Ether was added to the mixture and then water. The layers were separated. The aqueous phase was washed once with ether then acidified to a pH of about 3 with aqueous hydrochloric acid (6N). The aqueous phase was saturated with sodium chloride then extracted twice with ether. The combined ether extracts were washed with brine, dried (MgSO4) and concentrated to leave the title product as a yellow oil (10.7 g, 77%).

1. temperaturethen cooled with an ice bath
2. customThe layers were separated
3. washThe aqueous phase was washed once with ether
4. extractionthen extracted twice with ether
5. washThe combined ether extracts were washed with brine
6. dry with materialdried (MgSO4)
7. concentrationconcentrated

ORD-Eintrag

ord-a43b3531c77943dface0577e8c2daeb0

Quelldatensatz

uspto-grants-1992_06

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05118688