Sodium Iodide → HCID 9999073, Verbindung

HRID 892842Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 892842
CS(O[CH2:6][CH:7]1[O:12][C:11]2[CH:13]=[C:14]([O:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH:15]=[CH:16][C:10]=2[O:9][CH2:8]1)(=O)=O.[I-:24].[Na+]>C(C(C)=O)C.C(OCC)(=O)C>[I:24][CH2:6][CH:7]1[O:12][C:11]2[CH:13]=[C:14]([O:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH:15]=[CH:16][C:10]=2[O:9][CH2:8]1

Komponenten

5

Edukt 2

HCID 5238Sodium IodideHCID 10042628HCID 10042628, Verbindung

Produkt 1

HCID 9999073HCID 9999073, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6569Methyl Ethyl KetoneLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

2-Methanesulfonyloxymethyl-7-phenoxy-1,4-benzodioxane (1.85 g, 5.5 mmol) and sodium iodide (1.54 g, 11.0 mmol) are taken up in methyl ethyl ketone (60 mL) and heated at reflux for 3 hours. The mixture is cooled, diluted with ethyl acetate, washed with aqueous sodium bicarbonate, dried over magnesium sulfate and evaporated to give 2-iodomethyl-7-phenoxy-1,4-benzodioxane as a tan solid. This is used without further purification.

Aufarbeitung

  1. temperatureheated
  2. temperatureat reflux for 3 hours
  3. temperatureThe mixture is cooled
  4. washwashed with aqueous sodium bicarbonate
  5. dry with materialdried over magnesium sulfate
  6. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-5e011c08835541709630206838ac3f12
Quelldatensatz
uspto-grants-1992_06
Patentnummer
US05120758

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