Tetrahydrofuran → 6,11-Dihydro-11-hydroxydibenz[b,e]oxepin-2-carboxylic Acid

HRID 894200

Reaktionsgleichung

Reaktionsgleichung von HRID 894200
[OH:1][CH:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[CH2:6][O:5][C:4]2[CH:13]=[CH:14][C:15]([C:17]([O:19]C)=[O:18])=[CH:16][C:3]1=2.O1CCCC1.[OH-].[Na+]>O>[OH:1][CH:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[CH2:6][O:5][C:4]2[CH:13]=[CH:14][C:15]([C:17]([OH:19])=[O:18])=[CH:16][C:3]1=2

Komponenten

5

Edukt 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 2769059Methyl 11-hydroxy-6,11-dihydrobenzo[c][1]benzoxepine-2-carboxylate

Produkt 1

HCID 129291446,11-Dihydro-11-hydroxydibenz[b,e]oxepin-2-carboxylic Acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Dissolve 900 mg. of methyl 6,11-dihydro-11-hydroxydibenz[b,e]oxepin-2-carboxylate in 20 cc. of tetrahydrofuran. Add 20 cc. 1 N aqueous sodium hydroxide. Stir at room temperature for 48 hours. Dilute with water and extract with ether. Acidify the aqueous fraction with hydrochloric acid and extract with ether. Evaporate the organic phase to obtain the title product (m.p. 275° C. dec.).

Aufarbeitung

  1. dissolutionDissolve 900 mg
  2. additionAdd 20 cc
  3. extractionextract with ether
  4. extractionextract with ether
  5. customEvaporate the organic phase

Quellen und Nachweise

ORD-Eintrag
ord-06261300041049b7ae1e5f982962a19a
Quelldatensatz
uspto-grants-1981_08
Patentnummer
US04282365

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