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Sodium Iodide → 2-[2-(2,6-Dichloroanilino)phenyl]-N,N-dimethylacetamide

HRID 894397
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 894397
[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([Cl:9])[C:3]=1[NH2:4].[CH3:10][N:11]([CH3:22])[C:12](=[O:21])[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1Br.C(=O)([O-])[O-].[K+].[K+].[I-].[Na+]>C1(C)C(C)=CC=CC=1.[Cu].O>[CH3:22][N:11]([CH3:10])[C:12](=[O:21])[CH2:13][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:19]=1[NH:4][C:3]1[C:2]([Cl:1])=[CH:8][CH:7]=[CH:6][C:5]=1[Cl:9]
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

8

Edukt 4

HCID 5238Sodium IodideHCID 11430Potassium CarbonateHCID 118462,6-DichloroanilineHCID 128842292-(2-Bromophenyl)-N,N-dimethylacetamide

Produkt 1

HCID 128842302-[2-(2,6-Dichloroanilino)phenyl]-N,N-dimethylacetamide

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23978
Copper
Katalysator
HCID 962WaterLösungsmittel
HCID 7237O-XyleneLösungsmittel

Versuchsvorschrift

In 80 ml of xylene (having a boiling point of 138° to 141° C.), 8.5 g (0.0525 mole) of 2,6-dichloroaniline was refluxed together with 5.2 g (0.0215 mole) of N,N-dimethyl-o-bromophenylacetamide, 5.0 g (0.0357 mole) of potassium carbonate, 1.0 g of copper powder, 1.0 g of cuprous iodide and 2.0 g of sodium iodide for 48 hours under agitation, while water formed by the reaction was being separated. After completion of the reaction, the reaction mixture was treated with active carbon while it was still warm, and the filtrate was concentrated. The obtained residue was mixed with methyl alcohol and the crystal precipitated on cooling was recovered by filtration, washed with methyl alcohol and dried.

Aufarbeitung

  1. customformed by the reaction
  2. customwas being separated
  3. customAfter completion of the reaction
  4. additionthe reaction mixture was treated with active carbon while it
  5. temperaturewas still warm
  6. concentrationthe filtrate was concentrated
  7. additionThe obtained residue was mixed with methyl alcohol
  8. customthe crystal precipitated
  9. temperatureon cooling
  10. filtrationwas recovered by filtration
  11. washwashed with methyl alcohol
  12. customdried

Quellen und Nachweise

ORD-Eintrag
ord-fe076e463aa04bd58d29430088968f09
Quelldatensatz
uspto-grants-1981_08
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US04283532

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