Diethyl Ether → 2-(3-Methoxyphenyl)-2-methyloxirane

HRID 894918Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 894918
[CH3:1]S(C)(=O)=C.CO[CH:8](OC)[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:10].C[CH2:20][O:21]CC>CS(C)=O.O>[CH3:20][O:21][C:15]1[CH:16]=[C:11]([CH:12]=[CH:13][CH:14]=1)[C:9]1([CH3:8])[O:10][CH2:1]1

Komponenten

6

Edukt 3

HCID 3283Diethyl EtherHCID 2483332,2-Dimethoxy-1-phenylethanoneHCID 6396768Dimethylsulfoxonium methylide

Produkt 1

HCID 204969162-(3-Methoxyphenyl)-2-methyloxirane

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 679Dimethyl SulfoxideLösungsmittelHCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

To a solution of dimethylsulfoxonium methylide (69.4 mmoles) in dimethyl sulfoxide (65 ml.) at room temperature is added solid 3-l -dimethoxyacetophenone (8.33 g., 55.5 mmoles). The reaction mixture is stirred for one hour at 25° C., for one-half hour at 50° C. and is then cooled. The mixture is diluted with water (50 ml.) and added to a mixture of ice water (200 ml.)--ether (250 ml.)--low boiling petroleum ether (25 ml.). The organic extract is washed twice with water (250 ml.), dried (MgSO4) and evaporated to an oil which is fractionally distilled.

Aufarbeitung

  1. temperatureis then cooled
  2. extractionThe organic extract
  3. washis washed twice with water (250 ml.)
  4. dry with materialdried (MgSO4)
  5. customevaporated to an oil which
  6. distillationis fractionally distilled

Quellen und Nachweise

ORD-Eintrag
ord-23b5d1020e8f4ab59f87e7356365424b
Quelldatensatz
uspto-grants-1981_08
Patentnummer
US04284829

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