2-(4-Nitrophenoxy)naphthalene → 2-(4-Aminophenoxy)naphthalene

HRID 901701

Reaktionsgleichung

Reaktionsgleichung von HRID 901701
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([N+:18]([O-])=O)=[CH:14][CH:13]=1>CCO.[Pd]>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([NH2:18])=[CH:14][CH:13]=1

Komponenten

4

Edukt 1

HCID 7624782-(4-Nitrophenoxy)naphthalene

Produkt 1

HCID 35808292-(4-Aminophenoxy)naphthalene

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

The nitro intermediate (10 mmol) obtained above was dissolved in EtOH (50 mL) and hydrogenated in the presence of 10% Pd/C (300 mg) until completion according to General Procedure H, as indicated by TLC or HPLC. The reaction mixture was then filtered to remove the catalyst. The solvent was removed in vacuuo to afford the desired 4-(naphthalen-2-yloxy)aniline, which was used directly for further transformation without further purification.

Aufarbeitung

  1. filtrationThe reaction mixture was then filtered
  2. customto remove the catalyst
  3. customThe solvent was removed in vacuuo

Quellen und Nachweise

ORD-Eintrag
ord-4098d2e63ca645a590fc95b97a372b7b
Quelldatensatz
uspto-grants-2008_04
Patentnummer
US07361678B2

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