Water → 1-Azido-3-acetoxyacetone

HRID 903194

Reaktionsgleichung

Reaktionsgleichung von HRID 903194
Cl[CH2:2][C:3]([CH2:5][O:6][C:7](=[O:9])[CH3:8])=[O:4].O.[N-:11]=[N+:12]=[N-:13].[Na+]>O1CCCC1.CCOCC>[N:11]([CH2:2][C:3]([CH2:5][O:6][C:7](=[O:9])[CH3:8])=[O:4])=[N+:12]=[N-:13]

Komponenten

6

Edukt 3

HCID 962WaterHCID 33557Sodium AzideHCID 384132-Propanone, 1-(acetyloxy)-3-chloro-

Produkt 1

HCID 144347801-Azido-3-acetoxyacetone

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

1-Chloro-3-acetoxyacetone (15.05 g.) is dissolved in tetrahydrofuran (50 ml.) and water (25 ml.) is added. Sodium azide (8.7 g.) is added and the mixture is allowed to stir overnight at room temperature. The reaction mixture is diluted with ether (200 ml.) and the aqueous phase is separated. The organic phase is washed once with brine, then dried and evaporated to give 1-azido-3-acetoxyacetone.

Aufarbeitung

  1. customthe aqueous phase is separated
  2. washThe organic phase is washed once with brine
  3. customdried
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-cbfc365275df4b84be1e1ffe5a583ae4
Quelldatensatz
uspto-grants-1980_10
Patentnummer
US04226866

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