2-Oxobutanoic Acid → Thiazolidinecarboxylic acid, 2-ethyl-

HRID 903887

Reaktionsgleichung

Reaktionsgleichung von HRID 903887
Cl.[NH2:2][CH2:3][CH2:4][SH:5].C(N(CC)CC)C.O=[C:14]([CH2:18][CH3:19])[C:15]([OH:17])=[O:16]>C(O)C>[CH2:18]([C:14]1([C:15]([OH:17])=[O:16])[NH:2][CH2:3][CH2:4][S:5]1)[CH3:19]

Komponenten

5

Edukt 3

HCID 582-Oxobutanoic AcidHCID 8471TriethylamineHCID 9082Cysteamine Hydrochloride

Produkt 1

HCID 198462Thiazolidinecarboxylic acid, 2-ethyl-Ausbeute 65,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

11.4 g of cysteamine hydrochloride and 10.1 g of triethylamine were dissolved in 100 ml of ethanol, to which was added 10.2 g of 2-keto-butyric acid. The mixture was refluxed for 30 minutes, cooled and filtered thereby giving 10.6 g (yield 65.7%) of 2-ethyl-thiazolidine-2-carboxylic acid with a melting point of 235°-238° C. (decomposed).

Aufarbeitung

  1. temperatureThe mixture was refluxed for 30 minutes
  2. temperaturecooled
  3. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-6417e3b5d0cb4c31933f5935b2dc8ca2
Quelldatensatz
uspto-grants-1980_10
Patentnummer
US04229461

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