Nitric Acid → HCID 20478438, Verbindung

HRID 904681Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 904681
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11](=[O:13])[CH3:12])=[C:7]([OH:14])[C:6]=1[CH2:15][CH2:16][CH3:17])(=[O:3])[CH3:2].C(OC(=O)C)(=O)C.[N+:25]([O-])([OH:27])=[O:26]>C(O)(=O)C>[C:1]([NH:4][C:5]1[C:10]([N+:25]([O-:27])=[O:26])=[CH:9][C:8]([C:11](=[O:13])[CH3:12])=[C:7]([OH:14])[C:6]=1[CH2:15][CH2:16][CH3:17])(=[O:3])[CH3:2]

Komponenten

5

Edukt 3

HCID 944Nitric AcidHCID 7918Acetic AnhydrideHCID 2775203N1-(4-acetyl-3-hydroxy-2-propylphenyl)acetamide

Produkt 1

HCID 20478438HCID 20478438, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel2×

Versuchsvorschrift

1-(4-Acetylamino-2-hydroxy-3-propylphenyl)ethanone (58.75 g) was suspended in glacial acetic acid (750 ml), and this suspension was treated with a mixture of glacial acetic acid (250 ml), acetic anhydride (48 ml) and conc. nitric acid (10.2 ml) with vigorous stirring. After 18 hours the insoluble material was collected and dried in vacuo to afford the title compound 29.1 g. The structure was confirmed by NMR and mass spectrometry.

Aufarbeitung

  1. customAfter 18 hours the insoluble material was collected
  2. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-7cdc0735ca034538983991f8b9caf3f7
Quelldatensatz
uspto-grants-1983_12
Patentnummer
US04419352

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