Acetic Anhydride → n'-(4-Methoxyphenyl)acetohydrazide

HRID 906478

Reaktionsgleichung

Reaktionsgleichung von HRID 906478
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][NH2:10])=[CH:5][CH:4]=1.[C:11](OC(=O)C)(=[O:13])[CH3:12]>CCOCC>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][NH:10][C:11](=[O:13])[CH3:12])=[CH:5][CH:4]=1

Komponenten

4

Edukt 2

HCID 7918Acetic AnhydrideHCID 77023(4-Methoxyphenyl)hydrazine

Produkt 1

HCID 236267n'-(4-Methoxyphenyl)acetohydrazide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel2×

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

10 g of 4-methoxyphenylhydrazine hydrochloride are dissolved in water and then triethylamine is added until the salt has been neutralized. Extraction is carried out with AcOEt and then the extract is evaporated to dryness to produce 8 g of precipitate composed of 4-methoxyphenylhydrazine. This compound is dissolved in 30 ml of ether and then a solution of 13 ml of acetic anhydride dissolved in 30 ml of ether is added dropwise. The mixture is stirred at 0° C. for 15 minutes and then the white precipitate formed is filtered off to produce 7.4 g of the expected compound.

Aufarbeitung

  1. additionis added dropwise
  2. customthe white precipitate formed
  3. filtrationis filtered off

Quellen und Nachweise

ORD-Eintrag
ord-e564ea718d3046edbac9dd5f197dc1c2
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08012991B2

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