Ammonia → 5-(2-Chloroethyl)-1,3,4-thiadiazol-2-amine
Reaktionsgleichung
[NH2:1][NH:2][C:3]([NH2:5])=[S:4].[Cl:6][CH2:7][CH2:8][C:9](O)=O.O.N>S(=O)(=O)(O)O>[Cl:6][CH2:7][CH2:8][C:9]1[S:4][C:3]([NH2:5])=[N:2][N:1]=1Komponenten
6
Edukt 4
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 75 °C
Versuchsvorschrift
Thiosemicarbazide (10 g, 111 mmol) is added in portions to a solution of 3-chloropropionic acid (10 g, 92 mmol) in concentrated sulfuric acid. The mixture is heated with stirring at 75° C. for 1 hour. After cooling to room temperature the reaction mixture id added slowly to water and the resulting solution is brought to pH 7 by addition of aqueous ammonia solution. The titled product precipitates as a yellow solid which is removed by filtration and dried.
Aufarbeitung
- temperatureThe mixture is heated
- temperatureAfter cooling to room temperature the reaction mixture id
- customThe titled product precipitates as a yellow solid which
- customis removed by filtration
- customdried
Quellen und Nachweise
- ORD-Eintrag
- ord-900e21fc089548998abaeb12ea741dbe
- Quelldatensatz
- uspto-grants-2011_09
- Patentnummer
- US08017608B2
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