BROMINE CHLORIDE (BrCl) → HCID 178421697, Verbindung

HRID 910008

Reaktionsgleichung

Reaktionsgleichung von HRID 910008
C1(O[C:8](=O)[C:9]2[C:14]([OH:15])=[C:13]([C:16]([CH3:19])([CH3:18])[CH3:17])[CH:12]=[C:11]([Br:20])[C:10]=2[CH3:21])C=CC=CC=1.[NH2:23][C:24]1[CH:29]=[C:28]([Cl:30])[CH:27]=[CH:26][C:25]=1[S:31]([NH2:34])(=[O:33])=[O:32].BrCl>>[Br:20][C:11]1[CH:12]=[C:13]([C:16]([CH3:17])([CH3:18])[CH3:19])[C:14]([OH:15])=[C:9]([C:8]2[NH:34][S:31](=[O:33])(=[O:32])[C:25]3[CH:26]=[CH:27][C:28]([Cl:30])=[CH:29][C:24]=3[N:23]=2)[C:10]=1[CH3:21]

Komponenten

4

Edukt 3

HCID 61697BROMINE CHLORIDE (BrCl)HCID 777902-Amino-4-chlorobenzenesulphonamideHCID 574214533-Bromo-5-tert-butyl-6-hydroxy-2-methyl-benzoic acid phenyl ester

Produkt 1

HCID 178421697HCID 178421697, Verbindung

Versuchsvorschrift

From 3-bromo-5-tert-butyl-6-hydroxy-2-methyl-benzoic acid phenyl ester and 2-amino-4-chlorobenzenesulfonamide; obtained as white crystals following column chromatography (silica gel/EtOAc-heptane-CH2Cl2 1:6:3); mp 270-271° C. (decomp., ebullition); 1H NMR (DMSO): δ 12.58 (s, 1H, NH), 9.64 (s, 1H), 7.91 (d, J=8.3 Hz, 1H), 7.55 (dd, J˜8.3, 1.9 Hz, 1H), 7.48 (s, 1H), 7.34 (d, J=1.9 Hz, 1H), 2.20 (s, 3H), 1.37 (s, 9H); LC-MS: m/z 457/459/461 (M+H; BrCl isotope pattern), 935/937/939/941 (2M+Na; Br2Cl2 isotope pattern); Rt=2.24 min.

Aufarbeitung

  1. customobtained as white crystals

Quellen und Nachweise

ORD-Eintrag
ord-d6c87c5a32994af2a75162acd1d17b94
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08022066B2

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