Acetic Acid → 2-Amino-5-bromobenzene-1-thiol

HRID 910229

Reaktionsgleichung

Reaktionsgleichung von HRID 910229
[OH-].[K+].NC1[S:5][C:6]2[CH:12]=[C:11]([Br:13])[CH:10]=[CH:9][C:7]=2[N:8]=1.C(O)(=O)C>O>[NH2:8][C:7]1[CH:9]=[CH:10][C:11]([Br:13])=[CH:12][C:6]=1[SH:5]

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 14797Potassium HydroxideHCID 851492-Benzothiazolamine, 6-bromo-

Produkt 1

HCID 12090452-Amino-5-bromobenzene-1-thiolAusbeute 63,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Potassium hydroxide (39.6 g) was dissolved at 0° C. in water (80 mL), and 2-amino-6-bromobenzothiazole (6.87 g) was added to the solution, followed by refluxing under heating overnight. The mixture was returned to room temperature, and then neutralized with 5N aqueous acetic acid solution. The precipitated crystals were recovered through filtration, washed with water, and dried under reduced pressure with heating, followed by recrystallization from isopropyl ether, to thereby yield the title compound (3.87 g).

Aufarbeitung

  1. temperatureby refluxing
  2. temperatureunder heating overnight
  3. customwas returned to room temperature
  4. filtrationThe precipitated crystals were recovered through filtration
  5. washwashed with water
  6. customdried under reduced pressure
  7. temperaturewith heating
  8. customfollowed by recrystallization from isopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-95dfb255a5eb49f497aad75ae6f1451b
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08022075B2

Verknüpfte Notizen

Wird geladen…