Acetic Anhydride → N-(3,5-dimethoxyphenyl)acetamide

HRID 912548

Reaktionsgleichung

Reaktionsgleichung von HRID 912548
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH2:11])[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.[CH3:12][C:13](OC(C)=O)=[O:14].CCCCCC>C1(C)C=CC=CC=1>[CH3:10][O:9][C:7]1[CH:6]=[C:5]([NH:11][C:13](=[O:14])[CH3:12])[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=1

Komponenten

5

Edukt 3

HCID 7918Acetic AnhydrideHCID 8058HexaneHCID 663013,5-Dimethoxyaniline

Produkt 1

HCID 702039N-(3,5-dimethoxyphenyl)acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

To a solution of 3,5-dimethoxy-phenylamine (22.0 g, 143.6 mmol) in toluene (100 mL), is added slowly Ac2O (14 mL) at room temperature. After stirring 30 minutes, hexane (50 mL) is added with stirring at room temperature. The resulting solid is filtered and washed with hexane (50 mL) to offer designed product as a white solid 14.

Aufarbeitung

  1. stirringwith stirring at room temperature
  2. filtrationThe resulting solid is filtered
  3. washwashed with hexane (50 mL)

Quellen und Nachweise

ORD-Eintrag
ord-64bcb4283a7945a9bd9298d6aa0737d0
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08026243B2

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