5-(benzyloxy)-2-methylpyridin-4(1H)-one → 5-hydroxy-2-methylpyridin-4(1H)-one
Reaktionsgleichung
C([O:8][C:9]1[C:10](=[O:16])[CH:11]=[C:12]([CH3:15])[NH:13][CH:14]=1)C1C=CC=CC=1>CO.O.[Pd]>[OH:8][C:9]1[C:10](=[O:16])[CH:11]=[C:12]([CH3:15])[NH:13][CH:14]=1Komponenten
5
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 3
Versuchsvorschrift
A solution of 5-benzyloxy-2-methyl-1H-pyridin-4-one (2 g, 9.29 mmol) in methanol (30 ml) and water (8 ml) was placed in a Parr bottle. 10% Pd/C was added and the mixture was hydrogenated at 50 psi for 3 hours. A bed of CELITE™ was placed on a sintered glass, and washed with 0.1N HCl and then water. The content in the Parr bottle was removed from the Parr hydrogenator and flushed with nitrogen. The solution was filtered under suction. The filtrate was evaporated to give a white solid (820 mg, 70% yield).
Aufarbeitung
- washwashed with 0.1N HCl
- customThe content in the Parr bottle was removed from the Parr hydrogenator
- customflushed with nitrogen
- filtrationThe solution was filtered under suction
- customThe filtrate was evaporated
Quellen und Nachweise
- ORD-Eintrag
- ord-6b12319e6d6a4f97a51545aa6925c4e6
- Quelldatensatz
- uspto-grants-2011_09
- Patentnummer
- US08026261B2
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