[N:1]([O-:3])=O.[Na+].O.[CH:6]([N:9]1[C:14](=[O:15])[CH:13]=[CH:12][C:11]([CH2:16][C:17](=[O:24])[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[N:10]1)([CH3:8])[CH3:7]>CC(O)=O.CCOC(C)=O>[CH:6]([N:9]1[C:14](=[O:15])[CH:13]=[CH:12][C:11]([C:16](=[N:1][OH:3])[C:17]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:24])=[N:10]1)([CH3:8])[CH3:7]
A solution of sodium nitrite (1.725 g) of water (5.42 ml) was added in portions to a solution of 2-isopropyl-6-(2-oxo-2-phenylethyl)-3(2H)-pyridazinone (2.57 g) in a mixture of AcOH (2 ml) and EtOAc (8 ml) at 20-25° C. and the mixture was stirred at the same temperature for 8 hours. EtOAc was added to the mixture, washed with sat. aq. NaHCO3 solution and brine, dried over MgSO4 and concentrated under reduced pressure to give a solid. The solid was triturated with IPE and collected by filtration to give 1-(1-isopropyl-6-oxo-1,6-dihydro-3-pyridazinyl)-2-phenyl-1,2-ethanedione 1-oxime as a solid (1.71 g), which was identical to the authentic sample (the product of Preparation 1) by melting point and IR, MS and NMR spectra.
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