Hydrochloric Acid → 6-Amino-2-(trifluoromethyl)-1H-imidazo[4,5-b]pyridin-1-ol

HRID 917851Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 917851
[N+:1]([C:4]1[CH:5]=[C:6]2[N:12]([OH:13])[C:11]([C:14]([F:17])([F:16])[F:15])=[N:10][C:7]2=[N:8][CH:9]=1)([O-])=O.C(O)C.Cl.[H][H]>O.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]2[N:12]([OH:13])[C:11]([C:14]([F:15])([F:17])[F:16])=[N:10][C:7]2=[N:8][CH:9]=1

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 203554946-Nitro-2-(trifluoromethyl)-1H-imidazo[4,5-b]pyridin-1-olHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 203554676-Amino-2-(trifluoromethyl)-1H-imidazo[4,5-b]pyridin-1-ol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 962WaterLösungsmittel

Versuchsvorschrift

6-Nitro-1-hydroxy-2-(trifluoromethyl)-1H-imidazo(4,5-b)-pyridine (4.9 grams) was mixed with 100 milliliters of ethanol and 3 milliliters of concentrated hydrochloric acid, and 1 gram of 5 percent palladium or carbon was added to the mixture. The mixture was hydrogenated to a 3 mole-equivalent uptake of hydrogen. The reaction mixture was then filtered and evaporated, yielding a gummy solid residue which was taken up in 150 milliliters of water and used directly in the reaction reported in the following example.

Aufarbeitung

  1. additionwas added to the mixture
  2. filtrationThe reaction mixture was then filtered
  3. customevaporated
  4. customyielding a gummy solid residue which

Quellen und Nachweise

ORD-Eintrag
ord-811f71766df849f6b0f17243c0a958c3
Quelldatensatz
uspto-grants-1976_07
Patentnummer
US03968116

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