Hydrochloric Acid → 3-[4-(Hydroxymethyl)phenyl]propanoic acid
Reaktionsgleichung
C[CH:2]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][OH:14])=[CH:9][CH:8]=1)[C:3]([OH:5])=[O:4].[Li+].[OH-].Cl>CO.O>[OH:14][CH2:13][C:10]1[CH:11]=[CH:12][C:7]([CH2:6][CH2:2][C:3]([OH:5])=[O:4])=[CH:8][CH:9]=1Komponenten
6
Versuchsvorschrift
Intermediate B (5 g, 25.7 mmol) was dissolved in MeOH (50 mL) and water (10 mL). LiOH (1.85 g, 77.2 mmol) was added and the reaction stirred at RT for 18 h. The reaction mixture was acidified to pH ˜3 with 1M HCl, the resulting precipitate was isolated by filtration to afford the desired product (4.57 g, quant.). 1H NMR (300 MHz, d6-DMSO) δ: 7.18 (4H, q), 4.45 (2H, d), 2.81 (2H, t), 2.62 (2H, t).
Aufarbeitung
- customthe resulting precipitate was isolated by filtration
Quellen und Nachweise
- ORD-Eintrag
- ord-3e276ce1c7c5425b982a303dbcf8dc8b
- Quelldatensatz
- uspto-grants-2016_03
- Patentnummer
- US09273003B2
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