Water → (S)-1-Boc-3-methanesulfonyloxy-pyrrolidine
Reaktionsgleichung
[C:1]([N:8]1[CH2:12][CH2:11][C@H:10]([OH:13])[CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[CH3:14][S:15](Cl)(=[O:17])=[O:16].O>C1COCC1>[C:4]([O:3][C:1]([N:8]1[CH2:12][CH2:11][C@H:10]([O:13][S:15]([CH3:14])(=[O:17])=[O:16])[CH2:9]1)=[O:2])([CH3:7])([CH3:6])[CH3:5]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To 3.44 g (187 mmol) (S)-1-Boc-3-pyrrolidinol in 15 ml THF are added 1.70 mL (21.6 mmol) of methanesulfonyl chloride at 0° C. The reaction mixture is stirred for 1 h. Water is added and it is extracted with EtOAc (3×). The organic layer is washed with an aq. NaHCO3 solution and dried over MgSO4. The solvent is removed in vacuo.