I[CH2:2][CH3:3].Cl.[NH:5]1[CH2:9][CH2:8][C@@H:7]([CH2:10][C:11]#[N:12])[CH2:6]1.C(=O)([O-])[O-].[K+].[K+].O>CN(C=O)C>[CH2:2]([N:5]1[CH2:9][CH2:8][C@@H:7]([CH2:10][C:11]#[N:12])[CH2:6]1)[CH3:3]Iodoethane (10.1 g) was added to a mixture of 2-((S)-pyrrolidin-3-yl)acetonitrile hydrochloride (Intermediate 205, 7.9 g) and potassium carbonate (29.7 g) in DMF (20 mL) and the resultant mixture was stirred at room temperature for 5 hours. Water was added and the mixture was extracted with ethyl acetate, washed with brine, dried (Na2SO4) and filtered. The filtrate was evaporated to dryness to give 2-((S)-1-ethylpyrrolidin-3-yl)acetonitrile (3.8 g) as a yellow oil which was used without further characterisation.
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