2,4-Dichloropyrimidine → N-(1-pyridin-4-ylethyl)formamide

HRID 967468Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 967468
C(O)(=O)C.[NH:5]1[CH2:10][CH2:9][CH:8]([CH:11]([NH:13][CH:14]=[O:15])[CH3:12])[CH2:7][CH2:6]1.ClC1N=C(Cl)C=CN=1.C(N(C(C)C)C(C)C)C>C(O)C>[N:5]1[CH:10]=[CH:9][C:8]([CH:11]([NH:13][CH:14]=[O:15])[CH3:12])=[CH:7][CH:6]=1

Komponenten

5

Edukt 3

HCID 775312,4-DichloropyrimidineHCID 81531DiisopropylethylamineHCID 86599800HCID 86599800, Verbindung

Produkt 1

HCID 2771720N-(1-pyridin-4-ylethyl)formamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

N-(1-Piperidin-4-yl-ethyl)-formamide; compound with acetic acid (350 mg, 1.61 mmol), 2,4-dichloro-pyrimidine (265 mg, 1.78 mmol) and ethyl-diisopropyl-amine (848 mg, 6.56 mmol) in 20 ml of ethanol were heated under reflux for 5 hours. The mixture was evaporated and the residue dissolved in water and extracted with ethyl acetate. The organic layer was dried with MgSO4 and evaporated.

Aufarbeitung

  1. temperatureunder reflux for 5 hours
  2. customThe mixture was evaporated
  3. dissolutionthe residue dissolved in water
  4. extractionextracted with ethyl acetate
  5. dry with materialThe organic layer was dried with MgSO4
  6. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-35dac77553444a7fa1206542e86ca4d8
Quelldatensatz
uspto-grants-2005_10
Patentnummer
US06953857B2

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