Reaktionsgleichung
[O:1]=[C:2]1[C:7]([C:8]([NH:10][CH2:11][CH2:12][C:13](OCC)=O)=[O:9])=[CH:6][C:5]([C:18]2[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=2)=[N:4][NH:3]1.O=[C:25]1[C:30](C(O)=O)=[CH:29]C(C2C=CN=CC=2)=N[NH:26]1.ON1C2C=CC=CC=2N=N1.NCC1C=NC=CC=1.C(N(CC)C(C)C)(C)C.F[P-](F)(F)(F)(F)F.N1(OC(N(C)C)=[N+](C)C)C2N=CC=CC=2N=N1>CN(C)C=O>[O:1]=[C:2]1[C:7]([C:8]([NH:10][CH2:11][C:12]2[CH:13]=[N:26][CH:25]=[CH:30][CH:29]=2)=[O:9])=[CH:6][C:5]([C:18]2[CH:19]=[CH:20][N:21]=[CH:22][CH:23]=2)=[N:4][NH:3]1Komponenten
8
Edukt 6
HCID 310183-Pyridinemethanamine
HCID 757711-Hydroxybenzotriazole
HCID 81531Diisopropylethylamine
HCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)
HCID 10313657Ethyl 3-[(3-oxo-6-pyridin-4-yl-2,3-dihydropyridazine-4-carbonyl)amino]propionate
HCID 127902383-Oxo-6-(pyridin-4-yl)-2,3-dihydropyridazine-4-carboxylic acidProdukt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Working as in example 13 for the preparation of ethyl 3-[(3-oxo-6-pyridin-4-yl-2,3-dihydropyridazine-4-carbonyl)amino]propionate, but starting with 0.3 g of 3-oxo-6-pyridin-4-yl-2,3-dihydropyridazine-4-carboxylic acid, 30 cm3 of N,N-dimethylformamide, 0.233 g of 1-hydroxybenzotriazole, 0.18 cm3 of 3-(aminomethyl)pyridine, 0.31 cm3 of N,N-diisopropylethylamine and 0.65 g of O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate, 0.046 g of 3-oxo-6-pyridin-4-yl-N-(pyridin-3-ylmethyl)-2,3-dihydropyridazine-4-carboxamide was obtained in the form of a yellow solid melting at 262° C.
Quellen und Nachweise
- ORD-Eintrag
- ord-cca35768a9794907820a3e3904d52451
- Quelldatensatz
- uspto-grants-2007_12
- Patentnummer
- US07309701B2
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