Water → HCID 10702137, Verbindung

HRID 970678Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 970678
C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([N+:15]([O-])=O)=[CH:10][CH:9]=2)=O)C.[AlH4-].[Li+].O.[OH-].[Na+]>C1COCC1>[NH2:15][C:11]1[CH:12]=[C:13]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([CH2:4][OH:3])=[CH:14]2

Komponenten

6

Edukt 4

HCID 962Water2×HCID 14798Sodium HydroxideHCID 28112Lithium aluminum hydrideHCID 280312Ethyl 5-nitro-1H-indole-2-carboxylate

Produkt 1

HCID 10702137HCID 10702137, VerbindungAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

2-Ethoxycarbonyl-5-nitroindole (500 mg, 0.002 mol) was dissolved in 50 mL THF, added lithium tetrahydroaluminate (341 mg, 0.00898 mol) in 3 portions and stirred at room temperature overnight. Water (341 μL), 15% NaOH solution (341 μL), and water (1.1 mL) were added cautiously and the mixtured was filtered. The filtrate was concentrated under vacuum to give the product (300 mg, 98%) as an oil. m/z=162.9.

Aufarbeitung

  1. filtrationthe mixtured was filtered
  2. concentrationThe filtrate was concentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-d78c55ea0d11435795945981c1d200bf
Quelldatensatz
uspto-grants-2007_12
Patentnummer
US07312233B2

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