Water → 3-Methyl-1-phenyl-buten-3-ol

To a cooled (−10 to −5° C.) 165 mL of 3 M solution of methyl magnesium iodide in ether was added dropwise a solution of ethyl trans-cinnamate (25.0 g) in 200 mL of anhydrous ether. The reaction was warmed to room temperature and stirred overnight. The mixture was then heated up to 33° C. under reflux for two hours and cooled to 0° C. A white solid was formed during cooling and water (105 mL) was gradually added to dissolve the white precipitate followed by an additional 245 mL of saturated aqueous ammonium chloride solution. The mixture was then stirred until the solids were completely dissolved and extracted with 100 mL of ether three times. The combined extract was washed with 100 mL of water, dried over anhydrous sodium sulfate and filtered. The solvent was evaporated to give 22.1 g of the desired 4-phenyl-2-methyl-3-buten-2-ol as an oil which was used in the next step without further purification. 1H NMR (CDCl3, 300 MHz), δ(ppm) 7.41 (m, 5H), 6.58 (d, 1H), 6.34 (d, 1H), 1.41 (broad s, 6H).

1. temperatureThe mixture was then heated up to 33° C.
2. temperatureunder reflux for two hours
3. temperaturecooled to 0° C
4. customA white solid was formed
5. temperatureduring cooling
6. dissolutionto dissolve the white precipitate
7. stirringThe mixture was then stirred until the solids
8. dissolutionwere completely dissolved
9. extractionextracted with 100 mL of ether three times
10. extractionThe combined extract
11. washwas washed with 100 mL of water
12. dry with materialdried over anhydrous sodium sulfate
13. filtrationfiltered
14. customThe solvent was evaporated

ORD-Eintrag

ord-478ceff5298b4dfcb5dd6ea99134a591

Quelldatensatz

uspto-grants-2007_12

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07312247B2