Ammonium Hydroxide → HCID 15053448, Verbindung

HRID 974614Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 974614
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([O:6][CH:7]2[CH2:10][N:9]([C:11](Cl)=[O:12])[CH2:8]2)=[CH:4][CH:3]=1.[OH-].[NH4+:17]>O1CCCC1.O>[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([O:6][CH:7]2[CH2:10][N:9]([C:11]([NH2:17])=[O:12])[CH2:8]2)=[CH:4][CH:3]=1

Komponenten

5

Edukt 2

HCID 14923Ammonium HydroxideHCID 15042229HCID 15042229, Verbindung

Produkt 1

HCID 15053448HCID 15053448, VerbindungAusbeute 52,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of 5 g (0.02 mole) of 3-(4-chlorophenoxy)-1-azetidinecarbonyl chloride in 20 ml of tetrahydrofuran was stirred while 4 ml (0.06 mole) of 57% ammonium hydroxide was added all at once. After stirring for 18 hr, the reaction mixture was diluted with 200 ml of water and the solid which separated was collected by filtration, 10.5 g. Recrystallization from isopropanol yielded 2.4 g (52.9%) of gray crystalline powder, m.p. 187°-188° C.

Aufarbeitung

  1. additionwas added all at once
  2. customthe solid which separated
  3. filtrationwas collected by filtration, 10.5 g
  4. customRecrystallization from isopropanol

Quellen und Nachweise

ORD-Eintrag
ord-c6eb296d65eb4e44aed771720a40f514
Quelldatensatz
uspto-grants-1991_11
Patentnummer
US05068231

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