Thionyl Chloride → 2-Chloro-4,5-difluorobenzoyl chloride

HRID 974657Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 974657
S(Cl)(Cl)=O.S(Cl)(Cl)(=O)=O.P(Cl)(Cl)(Cl)(Cl)Cl.P(Cl)(Cl)([Cl:18])=O.[Cl:21][C:22]1[CH:30]=[C:29]([F:31])[C:28]([F:32])=[CH:27][C:23]=1[C:24](O)=[O:25]>O1CCOCC1.CS(C)=O.CN(C=O)C>[Cl:21][C:22]1[CH:30]=[C:29]([F:31])[C:28]([F:32])=[CH:27][C:23]=1[C:24]([Cl:18])=[O:25]

Komponenten

9

Edukt 5

HCID 24386Thionyl Chloride2×HCID 24648Sulfuryl chlorideHCID 24813Phosphorus oxychlorideHCID 24819Phosphorus pentachlorideHCID 7371712-Chloro-4,5-difluorobenzoic acid

Produkt 1

HCID 101982172-Chloro-4,5-difluorobenzoyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 679Dimethyl SulfoxideLösungsmittelHCID 6228DimethylformamideLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

In the chlorination of the reaction formula (a), thionyl chloride, sulfuryl chloride, phosphorus pentachloride or phosphorus oxychloride may be used as the chlorinating agents. Among them, thionyl chloride is preferred. The chlorination may be conducted by reacting 2-chloro-4,5-difluorobenzoic acid with the chlorinating agent at a reaction temperature of from 50° to 80° C. in an aprotic polar solvent such as DMF, DMSO or dioxane, or without a solvent, followed by isolation by a usual method such as distillation to obtain 2-chloro-4,5-difluorobenzoyl chloride.

Aufarbeitung

  1. customof from 50° to 80° C.
  2. distillationwithout a solvent, followed by isolation by a usual method such as distillation

Quellen und Nachweise

ORD-Eintrag
ord-70f3c678684f4c3fa51aec156f40c34f
Quelldatensatz
uspto-grants-1991_11
Patentnummer
US05068449

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