Sodium Dithionite → 2,5,6-Triamino-4-Benzyloxypyrimidine

HRID 976939Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 976939
S(S([O-])=O)([O-])=O.[Na+].[Na+].[N:9]([C:11]1[C:12]([NH2:26])=[N:13][C:14]([NH2:25])=[N:15][C:16]=1[O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=O>O>[NH2:25][C:14]1[N:13]=[C:12]([NH2:26])[C:11]([NH2:9])=[C:16]([O:17][CH2:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[N:15]=1

Komponenten

4

Edukt 2

HCID 24489Sodium DithioniteHCID 1810292,4-Pyrimidinediamine, 5-nitroso-6-(phenylmethoxy)-

Produkt 1

HCID 98160442,5,6-Triamino-4-Benzyloxypyrimidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Sodium dithionite is added in portions to a suspension of 17 g 5-nitroso-2,4-diamino-6-benzyloxy-primidine (8) in 300 mL H2O at 50° C. until the red nitroso compound is fully reduced. The free base is separated out by adding aqueous ammonia. The crude product is cooled, suctioned off and crystallized from water, to which activated charcoal and a trace of sodium dithionite is added yielding 9.

Aufarbeitung

  1. customThe free base is separated out
  2. additionby adding aqueous ammonia
  3. temperatureThe crude product is cooled
  4. customcrystallized from water, to which activated charcoal
  5. additiona trace of sodium dithionite is added
  6. customyielding 9

Quellen und Nachweise

ORD-Eintrag
ord-5eed9d62d29b4ff89a5319ce5cc955cb
Quelldatensatz
uspto-grants-1997_03
Patentnummer
US05612468

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