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Ammonium Chloride → (3S,4R)-4-[(1-Ethyl-5-methylpyrazol-3-yl)carbonylmethyl]-3-[(R)-1-tert-butyldimethylsilyloxyethyl]azetidin-2-one

HRID 976996
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[C:1]([C:4]1[CH:8]=[C:7]([CH3:9])[N:6]([CH2:10][CH3:11])[N:5]=1)(=[O:3])[CH3:2].C[Si]([N-][Si](C)(C)C)(C)C.[Li+].C(O[C@H:26]1[NH:29][C:28](=[O:30])[C@@H:27]1[C@H:31]([O:33][Si:34]([C:37]([CH3:40])([CH3:39])[CH3:38])([CH3:36])[CH3:35])[CH3:32])(=O)C.[Cl-].[NH4+]>O1CCCC1.O.C(OCC)(=O)C>[CH2:10]([N:6]1[C:7]([CH3:9])=[CH:8][C:4]([C:1]([CH2:2][C@H:26]2[NH:29][C:28](=[O:30])[C@@H:27]2[C@H:31]([O:33][Si:34]([C:37]([CH3:38])([CH3:40])[CH3:39])([CH3:36])[CH3:35])[CH3:32])=[O:3])=[N:5]1)[CH3:11]
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Komponenten

8

Edukt 4

HCID 25517Ammonium ChlorideHCID 2733832Lithium hexamethyldisilazaneHCID 10935078AzetidonHCID 221453691-(1-Ethyl-5-methyl-1H-pyrazol-3-yl)ethanone

Produkt 1

HCID 10691156(3S,4R)-4-[(1-Ethyl-5-methylpyrazol-3-yl)carbonylmethyl]-3-[(R)-1-tert-butyldimethylsilyloxyethyl]azetidin-2-oneAusbeute 41,9 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

3-Acetyl-1-ethyl-5-methylpyrazole (3.51 g) in dry tetrahydrofuran (THF) (150 ml) under an argon atmosphere was cooled in an acetone/solid carbon dioxide bath and then treated with a 1M solution of lithium bis(trimethylsilyl)amide (50 ml). The mixture was stirred for 45 minutes and then (3R,4R)-4-acetoxy-3-[(1R)-1-tert-butyldimethylsilyloxyethyl]azetidinone (6.6 g) was added as a solid under a blanket of argon. The mixture was stirred in the cold for 3.5 h. Saturated aqueous ammonium chloride was then added, followed by ethyl acetate, and the mixture was allowed to warm to room temperature. A little water was added and the layers were separated and the aqueous layer was re-extracted with ethyl acetate. The combined ethyl acetate extracts were washed with saturated brine, dried and evaporated. Chromatography on silica gel, eluting with ethyl acetate/hexane mixtures gave the title compound (3.65 g), νmax (CH2Cl2) 3411, 1761, 1678, 1376, 1151, and 838 cm-1 ; δ (CDCl3) 0.064 (6H, s), 0.86 (9H, s), 1.20 (3H,d, J 6.3 Hz), 1.44 (3H, t, J 7.3 Hz), 2.31 (3H, s), 2.89 (1H, dd, J 1.8 & 4.9 Hz), 3.15 (1H, dd, J 10.0 & 17.1 Hz), 3.50 (1H, dd, J 3.5 & 17.0 Hz), 4.06-4.25 (4H, m), 6.11 (1H, s) 6.53 (1H, s). (Found m/z 379.2296. C19H33N3O3Si requires m/z 379.2291).

Aufarbeitung

  1. stirringThe mixture was stirred in the cold for 3.5 h
  2. customthe layers were separated
  3. extractionthe aqueous layer was re-extracted with ethyl acetate
  4. washThe combined ethyl acetate extracts were washed with saturated brine
  5. customdried
  6. customevaporated
  7. washChromatography on silica gel, eluting with ethyl acetate/hexane mixtures

Quellen und Nachweise

ORD-Eintrag
ord-eed3bc1b0ba446f69dd2ed01567e54cf
Quelldatensatz
uspto-grants-1997_03
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US05612477

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